Phenotypes Associated with This Genotype

Genotype
MGI:3589448

• Allelic Composition: Ndst1^tm1.1Grob/Ndst1^tm1.1Grob; Shh^tm1Chg/Shh⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:100425 )

• 3-times fewer than expected mutants are produced

craniofacial

frontonasal prominence hypoplasia ( J:100425 )

• 4 of 5 mutants display severely hypoplastic frontonasal prominences similar to defects seen in severely affected Ndst1^tm1.1Grob single homozygotes

abnormal maxillary prominence morphology ( J:100425 )

• 4 of 5 mutants display severely hypoplastic maxillary prominences similar to defects seen in severely affected Ndst1^tm1.1Grob single homozygotes

nervous system

abnormal midbrain morphology ( J:100425 )

• all mutants display collapse of the midbrain

abnormal forebrain morphology ( J:100425 )

• all mutants display collapse of the forebrain