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Phenotypes Associated with This Genotype
Genotype
MGI:3589436
Allelic
Composition		 Alox5aptm1Bhk/Alox5aptm1Bhk
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alox5aptm1Bhk mutation (0 available); any Alox5ap mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to type I hypersensitivity reaction ( J:39229 )
• homozygotes are resistant to platelet-activating factor-induced anaphylaxis, with 75% of mutants (versus only 12.5% of wild-type mice) surviving this treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory