Mouse Genome Informatics
hm
    Ednrbs-l/Ednrbs-l
involves: C3H/HeJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most usually die by 15 days of age
• some live to breed but die between 3 and 15 months of age

pigmentation
• mice are white-coated with small patches of pigmented hair about the eyes,ears and tail

digestive/alimentary system
• distal four sections of the colon are aganglionic
• grossly evident via markedly distended colon in weaning age or older mice

nervous system
• deficiency of ganglion cells of the myenteric plexus of the lower colon

integument
• mice are white-coated with small patches of pigmented hair about the eyes,ears and tail

Mouse Models of Human Disease
OMIM IDRef(s)
Hirschsprung Disease, Susceptibility to, 2; HSCR2 600155 J:5008