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Phenotypes Associated with This Genotype
Genotype
MGI:3588984
Allelic
Composition		 Tg(Lck-CrmA)1Hed/?
Genetic
Background		 involves: BALB/c * C57BL/6J
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No mouse lines available in IMSR.
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:100451 )
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

hematopoietic system
decreased thymocyte apoptosis ( J:100451 )
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

cellular
decreased thymocyte apoptosis ( J:100451 )
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:100451 )
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory