Phenotypes Associated with This Genotype

Genotype
MGI:3588959

• Allelic Composition: Pax6^Sey/Pax6^Sey
• Genetic Background: B10.Cg-Pax6^Sey

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:8534 )

• mice are still viable at E11.5 but are seldom born

vision/eye

decreased eye pigmentation ( J:8534 )

• fail to develop eye pigment by E11.5 in mice that lack the lens

aphakia ( J:8534 )

• at E10.5, mice lack lenses

• however, optic vessicles are normal in size

nervous system

absent olfactory bulb ( J:8534 )

• at birth

respiratory system

abnormal nasal bone morphology ( J:8534 )

• only small frontonasal protuberances formed by E11.5 which later fuse with maxillary processes

absent nasal pit ( J:8534 )

• at E10.5, mice lack the nasal pit

craniofacial

abnormal nasal bone morphology ( J:8534 )

• only small frontonasal protuberances formed by E11.5 which later fuse with maxillary processes

absent nasal pit ( J:8534 )

• at E10.5, mice lack the nasal pit

pigmentation

decreased eye pigmentation ( J:8534 )

• fail to develop eye pigment by E11.5 in mice that lack the lens

skeleton

abnormal nasal bone morphology ( J:8534 )

• only small frontonasal protuberances formed by E11.5 which later fuse with maxillary processes

growth/size/body

abnormal nasal bone morphology ( J:8534 )

• only small frontonasal protuberances formed by E11.5 which later fuse with maxillary processes