Phenotypes Associated with This Genotype

Genotype
MGI:3588947

• Allelic Composition: Chek1^tm1Sje/Chek1⁺; Tg(Wnt1)1Hev/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:62919 )

• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene

• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation

integument

increased mammary adenocarcinoma incidence ( J:62919 )

• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene

• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:62919 )

• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene

• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation