Phenotypes Associated with This Genotype

Genotype
MGI:3588772

• Allelic Composition: Tsc1^tm1.1Djk/Tsc1^tm1.1Djk
• Genetic Background: either: 129S4/SvJae-Tsc1^tm1Djk or (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75243 )

• viability of embryos steadily declined from E9 to E13.5

• no viable null embryos were observed beyond E13.5

embryo

embryonic growth retardation ( J:75243 )

• typically by approximately one embryonic day less developed

liver/biliary system

liver hypoplasia ( J:75243 )

• hypoplastic liver with poorly developed other abdominal organs

• the liver and other abdominal organs had dilated vascular channels

homeostasis/metabolism

pericardial effusion ( J:75243 )

• viable E9-12.5 embryo often had pericardial effusions

hydrops fetalis ( J:75243 )

• viable E9-12.5 embryos are edematous

cardiovascular system

enlarged heart ( J:75243 )

• sightly enlarged heart that was shifted inferiorly

pericardial effusion ( J:75243 )

• viable E9-12.5 embryo often had pericardial effusions

growth/size/body

enlarged heart ( J:75243 )

• sightly enlarged heart that was shifted inferiorly

embryonic growth retardation ( J:75243 )

• typically by approximately one embryonic day less developed

integument

pallor ( J:75243 )

• viable E9-12.5 embryos are paler