Phenotypes Associated with This Genotype

Genotype
MGI:3588765

• Allelic Composition: F5^tm2Dgi/F5^tm2Dgi
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:66260 )

N • Background Sensitivity: decreased number of expected pups at 3 weeks of age but not at 1-2 days before birth, however do not observe lethality on a predominately C57BL/6J background

homeostasis/metabolism

abnormal blood coagulation ( J:66260 )

• more resistant to anticoagulant activated protein C than controls or heterozygotes, however F5 clotting activity is normal

abnormal thrombosis ( J:66260 )

• Background Sensitivity: widespread thrombosis affecting multiple organs, including brain, liver, heart, pancreas, and spleen, in all newborns

behavior/neurological

lethargy ( J:66260 )

• subset of mice appear lethargic at birth

integument

pallor ( J:66260 )

• subset of mice appear pale at birth