Mouse Genome Informatics
hm
    Tlr4lps-del/Tlr4lps-del
C57BL/10ScCr
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• poor activation of macrophage by Leishmania major
• higher levels of Th1 and Th2 cytokines secreted at 4 weeks after infection with Leishmania major than in controls
• response to endotoxin (LPS) prevented (J:51522)
• Leishmania major parasitic loads significantly higher than controls starting 24 hours after infection and persisting to 11 weeks after infection when controls are free of parasites (J:88996)

behavior/neurological
• attenuated mechanical allodynia after nerve injury
• attenuated response to heat

nervous system
• glial activation after nerve injury reduced

cardiovascular system
• exhibit reduced cardiac hypertrophy following pressure overload compared to controls

homeostasis/metabolism
• reduced spinal expression of TNF alpha, IFN gamma, IL-6 and IL-1 after injury
• glial activation after nerve injury reduced
• exhibit reduced cardiac hypertrophy following pressure overload compared to controls

integument
• attenuated mechanical allodynia after nerve injury
• attenuated response to heat

hematopoietic system
• poor activation of macrophage by Leishmania major

Mouse Models of Human Disease
OMIM IDRef(s)
Toll-Like Receptor 4; TLR4 603030 J:51522 , J:88996 , J:93263 , J:97819