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Phenotypes Associated with This Genotype
Genotype
MGI:3588730
Allelic
Composition
Tlr4lps-del/Tlr4lps-del
Genetic
Background
C57BL/10ScCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4lps-del mutation (5 available); any Tlr4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• poor activation of macrophage by Leishmania major (J:88996)
• poor activation of macrophage by Leishmania major (J:88996)
• higher levels of Th1 and Th2 cytokines secreted at 4 weeks after infection with Leishmania major than in controls (J:88996)
• higher levels of Th1 and Th2 cytokines secreted at 4 weeks after infection with Leishmania major than in controls (J:88996)
• response to endotoxin (LPS) prevented (J:51522)
• response to endotoxin (LPS) prevented (J:51522)
• Leishmania major parasitic loads significantly higher than controls starting 24 hours after infection and persisting to 11 weeks after infection when controls are free of parasites (J:88996)
• Leishmania major parasitic loads significantly higher than controls starting 24 hours after infection and persisting to 11 weeks after infection when controls are free of parasites (J:88996)

behavior/neurological
• attenuated mechanical allodynia after nerve injury (J:97819)
• attenuated mechanical allodynia after nerve injury (J:97819)
• attenuated response to heat (J:97819)
• attenuated response to heat (J:97819)

nervous system
• glial activation after nerve injury reduced (J:97819)
• glial activation after nerve injury reduced (J:97819)

cardiovascular system
• exhibit reduced cardiac hypertrophy following pressure overload compared to controls (J:106358)
• exhibit reduced cardiac hypertrophy following pressure overload compared to controls (J:106358)

homeostasis/metabolism
• reduced spinal expression of TNF alpha, IFN gamma, IL-6 and IL-1 after injury (J:97819)
• glial activation after nerve injury reduced (J:97819)
• reduced spinal expression of TNF alpha, IFN gamma, IL-6 and IL-1 after injury (J:97819)
• glial activation after nerve injury reduced (J:97819)
• exhibit reduced cardiac hypertrophy following pressure overload compared to controls (J:106358)
• exhibit reduced cardiac hypertrophy following pressure overload compared to controls (J:106358)

integument
• attenuated mechanical allodynia after nerve injury (J:97819)
• attenuated mechanical allodynia after nerve injury (J:97819)
• attenuated response to heat (J:97819)
• attenuated response to heat (J:97819)

hematopoietic system
• poor activation of macrophage by Leishmania major (J:88996)
• poor activation of macrophage by Leishmania major (J:88996)

Mouse Models of Human Disease
OMIM ID Ref(s)
Toll-Like Receptor 4; TLR4 603030 J:51522 , J:88996 , J:93263 , J:97819


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory