Phenotypes Associated with This Genotype

Genotype
MGI:3588673

• Allelic Composition: Cln8^mnd/Cln8⁺
• Genetic Background: involves: B6.KB2 * C57BL/6Fla

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal motor neuron morphology ( J:218228 , J:8492 )

• NOTE: It was originally thought that heterozygoous mice as old as 18 months could be visually identified; however, it has been impossible to repeat these results- no histological pathology is detectable. (J:218228)

• exhibit neurological disease, with onset of mild symptoms at an age (5 months) similar to homozygotes (J:8492)

• slower emergence of more severe motor neuron disease symptoms than in homozygotes (J:8492)