Phenotypes Associated with This Genotype

Genotype
MGI:3588670

• Allelic Composition: Tg(Lck-FADD)1Hed/?
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:100451 )

N • no indication of lymphoproliferative disease or development of CD3+B220+ population was observed out to 1.5 years of age

abnormal T cell physiology ( J:100451 )

• anti-CD95 plus cycloheximide fail to induce change in thymic mitochondrial potential

decreased thymocyte apoptosis ( J:100451 )

• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

hematopoietic system

abnormal T cell physiology ( J:100451 )

• anti-CD95 plus cycloheximide fail to induce change in thymic mitochondrial potential

decreased thymocyte apoptosis ( J:100451 )

• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

cellular

decreased thymocyte apoptosis ( J:100451 )

• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:100451 )

• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis