Phenotypes Associated with This Genotype

Genotype
MGI:3588669

• Allelic Composition: Tg(Lck-FADD)1Hed/Tg(Lck-FADD)1Hed
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:100451 )

N • normal levels of TCR surface expression

abnormal T cell differentiation ( J:100451 )

• partial block of thymocyte development at the CD25+CD44- stage of development just prior to proliferation

decreased T cell number ( J:100451 )

• T cell levels in spleen only 3% of normal levels at 3 to 4 weeks of age

decreased thymocyte number ( J:100451 )

• total number of thymocytes is approximately 35% that of wildtype littermates

hematopoietic system

abnormal T cell differentiation ( J:100451 )

• partial block of thymocyte development at the CD25+CD44- stage of development just prior to proliferation

decreased T cell number ( J:100451 )

• T cell levels in spleen only 3% of normal levels at 3 to 4 weeks of age

decreased thymocyte number ( J:100451 )

• total number of thymocytes is approximately 35% that of wildtype littermates

endocrine/exocrine glands

decreased thymocyte number ( J:100451 )

• total number of thymocytes is approximately 35% that of wildtype littermates