Analysis Tools
hematopoietic system
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• lymph node T cells respond almost normally to plate-bound anti-CD3 and anti-CD28 but are deficient in response to anti-CD3 and PMA or anti-CD3 and calcium ionophore
• unlike wildtype lymph node T cells or heterozygous thymocytes heterozygous lymph node T cells proliferate in response to PMA alone
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• partial block of thymocytes development at the CD25+CD44- stage of development just prior to proliferation
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• T cell levels in spleen only 20% of normal levels at 3 to 4 weeks of age
• CD4+ spleen and lymph node T cells increase with age to wild-type levels but CD8+ remain at low levels
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• decrease in total thymocyte number
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immune system
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• lymph node T cells respond almost normally to plate-bound anti-CD3 and anti-CD28 but are deficient in response to anti-CD3 and PMA or anti-CD3 and calcium ionophore
• unlike wildtype lymph node T cells or heterozygous thymocytes heterozygous lymph node T cells proliferate in response to PMA alone
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• partial block of thymocytes development at the CD25+CD44- stage of development just prior to proliferation
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• T cell levels in spleen only 20% of normal levels at 3 to 4 weeks of age
• CD4+ spleen and lymph node T cells increase with age to wild-type levels but CD8+ remain at low levels
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• decrease in total thymocyte number
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endocrine/exocrine glands
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• decrease in total thymocyte number
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cellular
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• lymph node T cells respond almost normally to plate-bound anti-CD3 and anti-CD28 but are deficient in response to anti-CD3 and PMA or anti-CD3 and calcium ionophore
• unlike wildtype lymph node T cells or heterozygous thymocytes heterozygous lymph node T cells proliferate in response to PMA alone
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