Phenotypes Associated with This Genotype

Genotype
MGI:3588645

• Allelic Composition: Tlr4^Lps-d/Tlr4^Lps-d
• Genetic Background: involves: C3H/HeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal osteoclast differentiation ( J:131353 )

• lipopolysaccharide fails to inhibit RANKL induced osteoclast formation as it does in controls

• antibody to IFN-beta or to IFNAR1 reverses inhibition of osteoclast formation induced by RANKL

abnormal T-helper 2 physiology ( J:96356 )

• Th2 responses elevated after induction of autoimmune arthritis

abnormal tumor necrosis factor level ( J:114368 , J:124334 )

• diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion (J:114368)

• macrophage primary but not secondary necrotic cells with residual stimulatory affect on TNF alpha production by macrophage (J:124334)

increased susceptibility to induced arthritis ( J:96356 )

• reduced susceptibility to arthritis induced by type II collagen

increased susceptibility to bacterial infection ( J:5721 , J:51522 , J:87807 )

• low responsiveness of spleen cells to lipopolysaccharides (J:5721)

• increased sensitivity to gram (-) infection (J:51522)

• significantly shortened survival after infection with Klebsiella pneumoniae (J:87807)

• increased K. pneumoniae levels in the lung (J:87807)

behavior/neurological

hyporesponsive to tactile stimuli ( J:97819 )

• reduced mechanical allodynia after nerve injury

increased thermal nociceptive threshold ( J:97819 )

• attenuated response to heat

skeleton

abnormal osteoclast differentiation ( J:131353 )

• lipopolysaccharide fails to inhibit RANKL induced osteoclast formation as it does in controls

• antibody to IFN-beta or to IFNAR1 reverses inhibition of osteoclast formation induced by RANKL

increased susceptibility to induced arthritis ( J:96356 )

• reduced susceptibility to arthritis induced by type II collagen

muscle

muscle phenotype ( J:116310 )

N • MCP-1 (monocyte chemoattractant protein-1) release from isolated mouse aorta smooth muscle cells (MAoSMC) by stimulation with dsRNA is normal relative to controls

nervous system

abnormal glial cell apoptosis ( J:99051 )

• isolated microglia exposed to LPS are resistant to apoptosis

homeostasis/metabolism

abnormal circulating enzyme level ( J:114368 )

• myeloperoxidase levels are reduced after 90 minutes of liver ischemia followed by 6 hours of reperfusion

• increased HO-1 expression

decreased circulating alanine transaminase level ( J:114368 )

• serum levels decreased after 90 minutes of liver ischemia followed by 6 hours of reperfusion

abnormal tumor necrosis factor level ( J:114368 , J:124334 )

• diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion (J:114368)

• macrophage primary but not secondary necrotic cells with residual stimulatory affect on TNF alpha production by macrophage (J:124334)

hematopoietic system

abnormal osteoclast differentiation ( J:131353 )

• lipopolysaccharide fails to inhibit RANKL induced osteoclast formation as it does in controls

• antibody to IFN-beta or to IFNAR1 reverses inhibition of osteoclast formation induced by RANKL

abnormal T-helper 2 physiology ( J:96356 )

• Th2 responses elevated after induction of autoimmune arthritis

cellular

abnormal glial cell apoptosis ( J:99051 )

• isolated microglia exposed to LPS are resistant to apoptosis

abnormal osteoclast differentiation ( J:131353 )

• lipopolysaccharide fails to inhibit RANKL induced osteoclast formation as it does in controls

• antibody to IFN-beta or to IFNAR1 reverses inhibition of osteoclast formation induced by RANKL

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:168789 )

N • cisplatin and lipopolysaccharide treatment does not lead to significant increases in auditory brainstem response as is observed in controls