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Phenotypes Associated with This Genotype
Genotype
MGI:3588645
Allelic
Composition
Tlr4Lps-d/Tlr4Lps-d
Genetic
Background
involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4Lps-d mutation (7 available); any Tlr4 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• lipopolysaccharide fails to inhibit RANKL induced osteoclast formation as it does in controls
• antibody to IFN-beta or to IFNAR1 reverses inhibition of osteoclast formation induced by RANKL
• Th2 responses elevated after induction of autoimmune arthritis
• diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion (J:114368)
• macrophage primary but not secondary necrotic cells with residual stimulatory affect on TNF alpha production by macrophage (J:124334)
• reduced susceptibility to arthritis induced by type II collagen
• low responsiveness of spleen cells to lipopolysaccharides (J:5721)
• increased sensitivity to gram (-) infection (J:51522)
• significantly shortened survival after infection with Klebsiella pneumoniae (J:87807)
• increased K. pneumoniae levels in the lung (J:87807)

behavior/neurological
• reduced mechanical allodynia after nerve injury
• attenuated response to heat

skeleton
• lipopolysaccharide fails to inhibit RANKL induced osteoclast formation as it does in controls
• antibody to IFN-beta or to IFNAR1 reverses inhibition of osteoclast formation induced by RANKL
• reduced susceptibility to arthritis induced by type II collagen

muscle
N
• MCP-1 (monocyte chemoattractant protein-1) release from isolated mouse aorta smooth muscle cells (MAoSMC) by stimulation with dsRNA is normal relative to controls

integument
• reduced mechanical allodynia after nerve injury
• attenuated response to heat

nervous system
• isolated microglia exposed to LPS are resistant to apoptosis

homeostasis/metabolism
• myeloperoxidase levels are reduced after 90 minutes of liver ischemia followed by 6 hours of reperfusion
• increased HO-1 expression
• serum levels decreased after 90 minutes of liver ischemia followed by 6 hours of reperfusion
• diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion (J:114368)
• macrophage primary but not secondary necrotic cells with residual stimulatory affect on TNF alpha production by macrophage (J:124334)

hematopoietic system
• lipopolysaccharide fails to inhibit RANKL induced osteoclast formation as it does in controls
• antibody to IFN-beta or to IFNAR1 reverses inhibition of osteoclast formation induced by RANKL
• Th2 responses elevated after induction of autoimmune arthritis

cellular
• isolated microglia exposed to LPS are resistant to apoptosis
• lipopolysaccharide fails to inhibit RANKL induced osteoclast formation as it does in controls
• antibody to IFN-beta or to IFNAR1 reverses inhibition of osteoclast formation induced by RANKL

hearing/vestibular/ear
N
• cisplatin and lipopolysaccharide treatment does not lead to significant increases in auditory brainstem response as is observed in controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Toll-Like Receptor 4; TLR4 603030 J:5721 , J:51522 , J:96356


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory