Phenotypes Associated with This Genotype

Genotype
MGI:3588575

• Allelic Composition: Ret^tm1Cos/Ret⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

nervous system

abnormal enteric neuron morphology ( J:82456 )

• colon submucosal neuron size is reduced by 16%, however cell size of small bowel submucosal neurons and myenteric and submucosal neuron numbers in the small bowel and colon are normal

• the myenteric plexus has a 35% reduction in cell size in the small bowel and 34% reduction in the colon

• myenteric neuron acetylcholinesterase-stained fiber counts are reduced by 11-13%

abnormal neurotransmitter secretion ( J:82456 )

• 70-95% reduction in substance P and VIP release

muscle

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation