Phenotypes Associated with This Genotype

Genotype
MGI:3588505

• Allelic Composition: Itga7^tm1Burk/Itga7^tm1Burk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:100236 )

• approximately 68% of homozygotes die before birth; surviving homozygotes are viable and fertile

cardiovascular system

abnormal blood vessel morphology ( J:100236 )

• reduced cerebral vascularization with hemorrhaging during embryonic development

abnormal vascular smooth muscle morphology ( J:100236 )

• histology of cerebral arteries from E13.5 homozygotes shows disrupted smooth muscle actin and hypoplasia

vascular smooth muscle hyperplasia ( J:100236 )

• histology of cerebral arteries of 5 week old homozygotes shows smooth muscle cell hyperplasia

vascular smooth muscle hypertrophy ( J:100236 )

• E13.5 cerebral vascular smooth muscle cells appear larger than normal

hemorrhage ( J:100236 )

• varying degrees of embryonic hemorrhaging, often associated with decreased cerebral vascularization

intracranial hemorrhage ( J:100236 )

• cerebrovascular hemorrhage and other vascular trauma found in E10.5-E14.5 embryos

muscle

abnormal vascular smooth muscle morphology ( J:100236 )

• histology of cerebral arteries from E13.5 homozygotes shows disrupted smooth muscle actin and hypoplasia

vascular smooth muscle hyperplasia ( J:100236 )

• histology of cerebral arteries of 5 week old homozygotes shows smooth muscle cell hyperplasia

vascular smooth muscle hypertrophy ( J:100236 )

• E13.5 cerebral vascular smooth muscle cells appear larger than normal

myopathy ( J:100236 )

• at 5 weeks of age, centrally located nuclei are found in approximately 17% of muscle fibers

nervous system

intracranial hemorrhage ( J:100236 )

• cerebrovascular hemorrhage and other vascular trauma found in E10.5-E14.5 embryos