Phenotypes Associated with This Genotype

Genotype
MGI:3588421

• Allelic Composition: Gdnf^tm1Bbd/Gdnf^tm1Bbd
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:33809 )

• die within the first day of life

renal/urinary system

absent kidney ( J:33809 )

abnormal ureteric bud invasion ( J:33809 )

• in mutant mice that do develop a ureteric bud, the bud never invades the metanepric mesenchyme

absent ureteric bud ( J:33809 )

• many mutant mice do not develop the ureteric bud

digestive/alimentary system

distended duodenum ( J:33809 )

• dilated duodenum, however the gonads and adrenal glands develop normally

pyloric stenosis ( J:33809 )

nervous system

absent enteric neurons ( J:33809 )

• no enteric neurons detected in the lower esophagus, stomach, small intestine or colon in newborns

abnormal superior cervical ganglion morphology ( J:33809 )

• 20% reduction in volume of superior cervical ganglion neurons

decreased motor neuron number ( J:33809 )

• 21% decrease in motor neuron number in the trigeminal motor nucleus

• 31% decrease in motor neuron number in the L4-L5 levels of the spinal cord, however no differences in facial motor neurons are observed