Phenotypes Associated with This Genotype

Genotype
MGI:3588100

• Allelic Composition: Anxa7^tm1Pll/Anxa7^tm1Pll
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:58572 )

• homozygous mutant embryos die at ~E10 due to cardiovascular defects; no viable embryos are obtained at E11

cardiovascular system

abnormal cardiovascular system physiology ( J:58572 )

intraventricular hemorrhage ( J:58572 )

• at E10, 8 of 40 mutant embryos display hemorrhages into the brain vesicles in the absence of other developmental anomalies

• such hemorrhages are composed of both mature maternal erythrocytes and fetal nucleated erythroid precursors

nervous system

intraventricular hemorrhage ( J:58572 )

• at E10, 8 of 40 mutant embryos display hemorrhages into the brain vesicles in the absence of other developmental anomalies

• such hemorrhages are composed of both mature maternal erythrocytes and fetal nucleated erythroid precursors