Phenotypes for Bmp5 MGI:3587920 MGI Mouse

abnormal right renal artery morphology ( J:5086 )

• the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls

abnormal digestive system morphology ( J:5086 )

• arrangement of the gut is irregular and variable in embryos

embryo phenotype ( J:5086 )

N	• Background Sensitivity: rarely see the left umbilical artery becoming the dominant artery as in the CBA/Ca background

abnormal embryonic tissue morphology ( J:5086 )

• crowding of the abdominal viscera in embryos

ectopic ovary ( J:5086 )

• Background Sensitivity: the left ovary frequently is displaced and lies at the anterior medial border of the kidney with the mesovarium and mesometrium attached near the medial border of the kidney

unilateral cryptorchism ( J:5086 )

• Background Sensitivity: the left testis occasionally is undescended and remains in the abdominal cavity

granulomatous inflammation ( J:5086 )

• granulomas are seen on the ventral surface of the central and left lateral lobes of the liver

abnormal forelimb morphology ( J:5086 )

• many E15-E17 embryos have a small papilla on the ulnar side of the fifth digit of the forefoot

short humerus ( J:5086 )

short femur ( J:5086 )

abnormal liver morphology ( J:5086 )

• Background Sensitivity: small umbilical hernia of the liver that occurs anterior to the loop of intestine in E13.5 embryos

• increase in liver lesions, mainly due to an increase in granulomas

renal/urinary system phenotype ( J:5086 )

N	• Background Sensitivity: hydroureter and hydronephrosis are rarely seen on the SEAC/Gn background like on the CBA/Ca background