Phenotypes Associated with This Genotype

Genotype
MGI:3587904

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: SEAC/Gn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta morphology ( J:5086 )

• the lateral branches of the aorta have a lower frequency of dorsal rami

abnormal right renal artery morphology ( J:5086 )

• the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls

embryo

abnormal embryonic tissue morphology ( J:5086 )

• crowding of the abdominal viscera in embryos

abnormal urogenital fold morphology ( J:5086 )

• both urogenital folds are abnormally shaped, being shorter and turned in more toward the midline than normal in embryos

umbilical hernia ( J:5086 )

• small umbilical hernia of the liver

endocrine/exocrine glands

ectopic ovary ( J:5086 )

♀ • the left ovary frequently is displaced and lies at the anterior medial border of the kidney with the mesovarium and mesometrium attached near the medial border of the kidney

unilateral cryptorchism ( J:5086 )

♂ • the left testis occasionally is undescended and remains in the abdominal cavity

immune system

granulomatous inflammation ( J:5086 )

• granulomas are seen on the ventral surface of the central and left lateral lobes of the liver

limbs/digits/tail

abnormal forelimb morphology ( J:5086 )

• many E15-E17 embryos have a small papilla on the ulnar side of the fifth digit of the forefoot

short humerus ( J:5086 )

short femur ( J:5086 )

liver/biliary system

abnormal liver morphology ( J:5086 )

• increase in liver lesions, mainly due to an increase in granulomas

• small umbilical hernia of the liver

renal/urinary system

abnormal right renal artery morphology ( J:5086 )

• the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls

hydronephrosis ( J:5086 )

• occasionally observe hydronephrosis

hydroureter ( J:5086 )

• occasionally observe hydroureter

reproductive system

ectopic ovary ( J:5086 )

♀ • the left ovary frequently is displaced and lies at the anterior medial border of the kidney with the mesovarium and mesometrium attached near the medial border of the kidney

unilateral cryptorchism ( J:5086 )

♂ • the left testis occasionally is undescended and remains in the abdominal cavity

respiratory system

lung cyst ( J:5086 )

• have numerous small cysts in the lungs

skeleton

short humerus ( J:5086 )

short femur ( J:5086 )

growth/size/body

lung cyst ( J:5086 )

• have numerous small cysts in the lungs