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Phenotypes Associated with This Genotype
involves: DBA/2 * T STOCK
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NhsXcat mutation (0 available); any Nhs mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• in the first postnatal week, degeneration of the lens nucleus and cortical fibers continues
• by the second postnatal week, lenses appear amorphous except at the epithelium and at the equitorial cortex
• at E15, lens material extrudes through minute defects in the capsule; also observed at subsequent ages
• by P21, rupture of the lens capsule is seen in all mice
• at E14, small vacuoles appear in the center of the developing lens
• by E17 and E18, these vacuoles expand to form large cavities
• at E14, an irregular arrangement of round primary fibers is seen, in contrast to the elongated fibers of control lenses
• at E15, the primary fibers in the center of the lens contain larger vacuoles and show evidence of dissolution, but peripheral fibers appear normal
• at E17-E18, vacuoles are seen in secondary lens fibers, indicating degeneration
• by the first postnatal week, cytological architecture is no longer recognizable in the primary fibers
• total lens opacity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Nance-Horan syndrome DOID:0060599 OMIM:302350
J:19674 , J:89306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory