Mouse Genome Informatics
involves: DBA/2 * T STOCK
phenotype observed in females
phenotype observed in males
N normal phenotype
• in the first postnatal week, degeneration of the lens nucleus and cortical fibers continues
• by the second postnatal week, lenses appear amorphous except at the epithelium and at the equitorial cortex
• at E15, lens material extrudes through minute defects in the capsule; also observed at subsequent ages
• by P21, rupture of the lens capsule is seen in all mice
• at E14, small vacuoles appear in the center of the developing lens
• by E17 and E18, these vacuoles expand to form large cavities
• at E14, an irregular arrangement of round primary fibers is seen, in contrast to the elongated fibers of control lenses
• at E15, the primary fibers in the center of the lens contain larger vacuoles and show evidence of dissolution, but peripheral fibers appear normal
• at E17-E18, vacuoles are seen in secondary lens fibers, indicating degeneration
• by the first postnatal week, cytological architecture is no longer recognizable in the primary fibers
• total lens opacity

Mouse Models of Human Disease
Nance-Horan Syndrome; NHS 302350 J:19674 , J:89306