Phenotypes Associated with This Genotype

Genotype
MGI:3587506

• Allelic Composition: Jag1^Slalom/Jag1⁺
• Genetic Background: involves: BALB/c * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

head shaking ( J:67728 )

• subtle headweaving/shaking behavior

positive geotaxis ( J:67728 )

• described as poor negative geotaxis

hearing/vestibular/ear

abnormal cochlear sensory epithelium morphology ( J:67728 )

• supernumary or atypical outer hair cells sometimes found in inner hair cell rows

decreased cochlear outer hair cell number ( J:67728 )

• reduced numbers of outer hair cells

• some regions lacking entire rows while isolated hair cells missing in other regions

• decreased outer hair cell counts in both basal and apical turns

increased cochlear inner hair cell number ( J:67728 )

• significantly increased inner hair cell counts in base of cochlea but not apical regions

abnormal semicircular canal morphology ( J:67728 )

• either posterior or anterior semicircular canal truncated

• sometimes both anterior and posterior semicircular canals absent

abnormal semicircular canal ampulla morphology ( J:67728 )

• absence of ampullae

nervous system

decreased cochlear outer hair cell number ( J:67728 )

• reduced numbers of outer hair cells

• some regions lacking entire rows while isolated hair cells missing in other regions

• decreased outer hair cell counts in both basal and apical turns

increased cochlear inner hair cell number ( J:67728 )

• significantly increased inner hair cell counts in base of cochlea but not apical regions