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Phenotypes Associated with This Genotype
Genotype
MGI:3587031
Allelic
Composition
Hoxa13Hd/Hoxa13+
Genetic
Background
B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13Hd mutation (1 available); any Hoxa13 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• decrease in the number of duct tips in the ampullary gland
• 29% have one lobe of the coagulating gland duct that has a single main duct
• decrease in the number of duct tips in the dorsal and lateral divisions of the dorsolateral prostate and the ventral prostate
• 57% have a smaller dorsal prostate, 43% have a smaller lateral prostate, and 43% have a smaller ventral prostate
• 43% have a smaller ventral prostate
• seminal vesicles have an altered curvature and spiked clefting and lack the secondary and tertiary branches
• little secondary and tertiary branching is observed
• 86% have seminal vesicles that are two thirds the size of wild-type

reproductive system
• decrease in the number of duct tips in the ampullary gland
• 29% have one lobe of the coagulating gland duct that has a single main duct
• decrease in the number of duct tips in the dorsal and lateral divisions of the dorsolateral prostate and the ventral prostate
• 57% have a smaller dorsal prostate, 43% have a smaller lateral prostate, and 43% have a smaller ventral prostate
• 43% have a smaller ventral prostate
• seminal vesicles have an altered curvature and spiked clefting and lack the secondary and tertiary branches
• little secondary and tertiary branching is observed
• 86% have seminal vesicles that are two thirds the size of wild-type
• exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype

Mouse Models of Human Disease
OMIM ID Ref(s)
Hand-Foot-Genital Syndrome; HFG 140000 J:54823


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory