Mouse Genome Informatics
hm
    Hoxa13Hd/Hoxa13Hd
involves: MYA/Hu
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most die before E16, though a few survive to maturity

growth/size/body

reproductive system

limbs/digits/tail
• short single digit on each paw that has a terminal claw (J:5211)
• progression of ectrodactyly appears to be from pre- to postaxial sites, with the forepaw showing more advanced ectrodactyly than the hind paw, seen in the few homozygotes that survive to maturity
• single short digit on each fore and hind foot (J:64253)
• tarsal defects in the few homozygotes that survive to maturity
• carpals are misshapen, fused, and missing in the few homozygotes that survive to maturity
• metacarpal defects in the few homozygotes that survive to maturity
• metatarsal defects in the few homozygotes that survive to maturity

renal/urinary system
• some that die neonatally have severe hydronephrosis

skeleton
• tarsal defects in the few homozygotes that survive to maturity
• carpals are misshapen, fused, and missing in the few homozygotes that survive to maturity
• metacarpal defects in the few homozygotes that survive to maturity
• metatarsal defects in the few homozygotes that survive to maturity

Mouse Models of Human Disease
OMIM IDRef(s)
Hand-Foot-Genital Syndrome; HFG 140000 J:5211 , J:64253