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Phenotypes Associated with This Genotype
Genotype
MGI:3587024
Allelic
Composition
Hoxa13Hd/Hoxa13Hd
Genetic
Background
involves: MYA/Hu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13Hd mutation (1 available); any Hoxa13 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die before E16, though a few survive to maturity

growth/size/body

reproductive system

limbs/digits/tail
• short single digit on each paw that has a terminal claw (J:5211)
• progression of ectrodactyly appears to be from pre- to postaxial sites, with the forepaw showing more advanced ectrodactyly than the hind paw, seen in the few homozygotes that survive to maturity
• single short digit on each fore and hind foot (J:64253)
• tarsal defects in the few homozygotes that survive to maturity
• carpals are misshapen, fused, and missing in the few homozygotes that survive to maturity
• metacarpal defects in the few homozygotes that survive to maturity
• metatarsal defects in the few homozygotes that survive to maturity

renal/urinary system
• some that die neonatally have severe hydronephrosis

skeleton
• tarsal defects in the few homozygotes that survive to maturity
• carpals are misshapen, fused, and missing in the few homozygotes that survive to maturity
• metacarpal defects in the few homozygotes that survive to maturity
• metatarsal defects in the few homozygotes that survive to maturity

Mouse Models of Human Disease
OMIM ID Ref(s)
Hand-Foot-Genital Syndrome; HFG 140000 J:5211 , J:64253


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory