Phenotypes Associated with This Genotype

Genotype
MGI:3584532

• Allelic Composition: Ipmk^tm1Yrk/Ipmk^tm1Yrk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphological analysis of Ipmk^tm1Yrk/Ipmk^tm1Yrk embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:99723 )

• homozygous embryos die between E10.5 and E12.5

embryo

incomplete embryo turning ( J:99723 )

• at E9.5 homozygous embryos are not turned

embryonic growth retardation ( J:99723 )

• at E8.5 embryos appear developmentally delayed

decreased embryo size ( J:99723 )

• at E8.5 homozygous embryos are smaller and shorter along the anterior to posterior axis

• at E9.5 homozygous embryos are about 20% smaller than their littermates

open neural tube ( J:99723 )

• at E9.5 the anterior neural tube is open

kinked neural tube ( J:99723 )

• at E9.5 the neural tube is kinked and folded

failure of chorioallantoic fusion ( J:99723 )

• at E8.5 and E9.5, the allantois is not fused to the chorion

nervous system

open neural tube ( J:99723 )

• at E9.5 the anterior neural tube is open

kinked neural tube ( J:99723 )

• at E9.5 the neural tube is kinked and folded

abnormal brain development ( J:99723 )

• at E8.5 massive accumulation and folding of the neurectoderm is seen in the mid-hind region

growth/size/body

embryonic growth retardation ( J:99723 )

• at E8.5 embryos appear developmentally delayed

decreased embryo size ( J:99723 )

• at E8.5 homozygous embryos are smaller and shorter along the anterior to posterior axis

• at E9.5 homozygous embryos are about 20% smaller than their littermates