Phenotypes Associated with This Genotype

Genotype
MGI:3584502

• Allelic Composition: Il5ra^tm1Ktk/Il5ra^tm1Ktk; Lyn^tm1Tya/Lyn^tm1Tya
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-1 B cell number ( J:91089 )

• IgM(+) B1 cells reduced about 35%

increased immunoglobulin level ( J:91089 )

increased IgA level ( J:91089 )

• moderately

increased IgM level ( J:91089 )

• moderately

abnormal immune system organ morphology ( J:91089 )

enlarged spleen ( J:91089 )

abnormal spleen white pulp morphology ( J:91089 )

• large lymphoblast-like cells and reticular cells accumulate in white pulp

abnormal spleen B cell corona morphology ( J:91089 )

• decreased numbers of mature lymphocytes

enlarged lymph nodes ( J:91089 )

• enlarged

increased anti-double stranded DNA antibody level ( J:91089 )

• anti dsDNA autoantibodies elevated

glomerulonephritis ( J:91089 )

renal/urinary system

glomerulonephritis ( J:91089 )

hematopoietic system

enlarged spleen ( J:91089 )

decreased B-1 B cell number ( J:91089 )

• IgM(+) B1 cells reduced about 35%

abnormal spleen white pulp morphology ( J:91089 )

• large lymphoblast-like cells and reticular cells accumulate in white pulp

abnormal spleen B cell corona morphology ( J:91089 )

• decreased numbers of mature lymphocytes

increased immunoglobulin level ( J:91089 )

increased IgA level ( J:91089 )

• moderately

increased IgM level ( J:91089 )

• moderately

growth/size/body

enlarged spleen ( J:91089 )