Mouse Genome Informatics
hm
    Spry2tm1Ayos/Spry2tm1Ayos
B6.Cg-Spry2tm1Ayos
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• about half die within 6 weeks after birth, with many of the remaining homozygotes surviving for at least 6 months

growth/size

digestive/alimentary system
• exhibit esophageal achalasia, showing a dilated esophagous that is clogged with saburra in 4 week or older mice
• intestinal gauge is partly dilated and filled with gas at 2 months of age
• contraction force of the lower esophageal sphincter in response to carbachol is more than 5 times stronger than in wild-type
• motility of the intestine in response to carbachol is abnormal
• intestinal pseudo-obstruction

nervous system
• enteric nervous system hyperplasia
• hypergangliosis of the enteric nervous system
• enteric nerve hyperplasia

Mouse Models of Human Disease
OMIM IDRef(s)
Achalasia, Familial Esophageal 200400 J:99827
Neuronal Intestinal Dysplasia, Type B 601223 J:99827