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Phenotypes Associated with This Genotype
Genotype
MGI:3584494
Allelic
Composition
Spry2tm1Ayos/Spry2tm1Ayos
Genetic
Background
B6.Cg-Spry2tm1Ayos
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about half die within 6 weeks after birth, with many of the remaining homozygotes surviving for at least 6 months (J:99827)
• about half die within 6 weeks after birth, with many of the remaining homozygotes surviving for at least 6 months (J:99827)

growth/size/body

digestive/alimentary system
• exhibit esophageal achalasia, showing a dilated esophagous that is clogged with saburra in 4 week or older mice (J:99827)
• exhibit esophageal achalasia, showing a dilated esophagous that is clogged with saburra in 4 week or older mice (J:99827)
• intestinal gauge is partly dilated and filled with gas at 2 months of age (J:99827)
• intestinal gauge is partly dilated and filled with gas at 2 months of age (J:99827)
• contraction force of the lower esophageal sphincter in response to carbachol is more than 5 times stronger than in wild-type (J:99827)
• motility of the intestine in response to carbachol is abnormal (J:99827)
• contraction force of the lower esophageal sphincter in response to carbachol is more than 5 times stronger than in wild-type (J:99827)
• motility of the intestine in response to carbachol is abnormal (J:99827)
• intestinal pseudo-obstruction (J:99827)
• intestinal pseudo-obstruction (J:99827)

nervous system
• enteric nervous system hyperplasia (J:99827)
• enteric nervous system hyperplasia (J:99827)
• hypergangliosis of the enteric nervous system (J:99827)
• hypergangliosis of the enteric nervous system (J:99827)
• enteric nerve hyperplasia (J:99827)
• enteric nerve hyperplasia (J:99827)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory