About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3584463
Allelic
Composition
Trp53tm2.1Tyj/Trp53+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2.1Tyj mutation (2 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean life span is 15.2 months

neoplasm
• tumors metastisize more frequently than those in Trp53tm1Tyj or Trp53tm3.1Tyj heterozygotes

cellular
• resistance to gamma-irradiation induced apoptosis is increased compared to Trp53tm1Tyj heterozygotes
• a larger fraction of MEFs are in S phase compared to Trp53tm1Tyj hterozygotes; however DNA damage-induced G1 arrest is intact

skeleton
• diffuse osteopetrosis is frequently observed with osteosarcomas

Mouse Models of Human Disease
OMIM ID Ref(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95316


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory