Mouse Genome Informatics
ht
    Trp53tm2.1Tyj/Trp53+
involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mean life span is 15.2 months

tumorigenesis
• tumors metastisize more frequently than those in Trp53tm1Tyj or Trp53tm3.1Tyj heterozygotes

cellular
• resistance to gamma-irradiation induced apoptosis is increased compared to Trp53tm1Tyj heterozygotes
• a larger fraction of MEFs are in S phase compared to Trp53tm1Tyj hterozygotes; however DNA damage-induced G1 arrest is intact

skeleton
• diffuse osteopetrosis is frequently observed with osteosarcomas

Mouse Models of Human Disease
OMIM IDRef(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95316