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Phenotypes Associated with This Genotype
Genotype
MGI:3584454
Allelic
Composition
Emx1tm1(cre)Ito/?
Gt(ROSA)26Sortm1(HD*103Q)Xwy/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (19 available)
Gt(ROSA)26Sortm1(HD*103Q)Xwy mutation (1 available); any Gt(ROSA)26Sor mutation (375 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice have comparable locomotor activity to wild-type controls
• gliosis levels are comparable to wild-type
• dendrites with abnormal or wavy morphology occur with similar frequency in mutants and wild-type controls
• very few neurons showing early stages of degeneration are observed
• electrophysiology such as sIPSCs from cortical neurons are normal relative to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT Huntington's disease DOID:12858 OMIM:143100
J:99759


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory