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Phenotypes Associated with This Genotype
Genotype
MGI:3584347
Allelic
Composition		 Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Tg(Col2a1-PTHLH)1Ecw/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Pthlhtm1Hmk mutation (0 available); any Pthlh mutation (19 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
Tg(Col2a1-PTHLH)1Ecw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
long tibia ( J:99641 )
• increase in tibia length
abnormal long bone epiphyseal plate morphology ( J:99641 )
• exhibit ectopically differentiated chondrocytes
abnormal chondrocyte differentiation ( J:99641 )
• eutopic hypertrophic chondrocyte differentiation is stimulated

limbs/digits/tail
long tibia ( J:99641 )
• increase in tibia length

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory