Mouse Genome Informatics
hm
    Irak3tm1Flv/Irak3tm1Flv
involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Small size and reduced total bone mineral density in Irak3tm1Flv/Irak3tm1Flv mice

immune system
• increased numbers of polymorphonuclear cells found in Peyer's patches
• increased numbers of osteoclasts per unit area of bone surface
• shows hemorrhaging
• grossly enlarged after infection with gram negative bacteria
• increased amounts of Il12p40 produced by macrophage when challenged by either gram negative or gram positive bacteria
• increased amounts produced by macrophage when challenged by either gram negative or gram positive bacteria
• increased amounts produced by macrophage when challenged by gram negative bacteria
• decreased tolerance to endotoxin
• enhanced innate immunity
• bacterial load not greatly increased in spleens of mice with bacterial infections
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly
• osteoclasts are generated more rapidly and have more prolonged life spans

skeleton
• increased numbers of osteoclasts per unit area of bone surface
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly
• osteoclasts are generated more rapidly and have more prolonged life spans
• decreased diameter of the femur in both sexes
• develops by 4 months of age
• lower cortical bone content at 4 months of age in the femur
• cortical thickness of the femur reduced in males
• increased numbers of osteoblasts seen in males
• trabecular bone content at epiphyses reduced
• 60% reduction in trabecular bone volume

growth/size/body
• by 4 months of age

hematopoietic system
• increased numbers of polymorphonuclear cells found in Peyer's patches
• increased numbers of osteoclasts per unit area of bone surface
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly
• osteoclasts are generated more rapidly and have more prolonged life spans

limbs/digits/tail
• decreased diameter of the femur in both sexes

Mouse Models of Human Disease
OMIM IDRef(s)
Osteoporosis 166710 J:98035