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Phenotypes Associated with This Genotype
Genotype
MGI:3584247
Allelic
Composition
Irak3tm1Flv/Irak3tm1Flv
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak3tm1Flv mutation (2 available); any Irak3 mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Small size and reduced total bone mineral density in Irak3tm1Flv/Irak3tm1Flv mice

immune system
• increased numbers of polymorphonuclear cells found in Peyer's patches (J:78189)
• increased numbers of polymorphonuclear cells found in Peyer's patches (J:78189)
• increased numbers of osteoclasts per unit area of bone surface (J:98035)
• increased numbers of osteoclasts per unit area of bone surface (J:98035)
• shows hemorrhaging (J:78189)
• shows hemorrhaging (J:78189)
• grossly enlarged after infection with gram negative bacteria (J:78189)
• grossly enlarged after infection with gram negative bacteria (J:78189)
• increased amounts of Il12p40 produced by macrophage when challenged by either gram negative or gram positive bacteria (J:78189)
• increased amounts of Il12p40 produced by macrophage when challenged by either gram negative or gram positive bacteria (J:78189)
• increased amounts produced by macrophage when challenged by either gram negative or gram positive bacteria (J:78189)
• increased amounts produced by macrophage when challenged by either gram negative or gram positive bacteria (J:78189)
• increased amounts produced by macrophage when challenged by gram negative bacteria (J:78189)
• increased amounts produced by macrophage when challenged by gram negative bacteria (J:78189)
• decreased tolerance to endotoxin (J:78189)
• decreased tolerance to endotoxin (J:78189)
• enhanced innate immunity (J:78189)
• bacterial load not greatly increased in spleens of mice with bacterial infections (J:78189)
• enhanced innate immunity (J:78189)
• bacterial load not greatly increased in spleens of mice with bacterial infections (J:78189)
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly (J:98035)
• osteoclasts are generated more rapidly and have more prolonged life spans (J:98035)
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly (J:98035)
• osteoclasts are generated more rapidly and have more prolonged life spans (J:98035)

skeleton
• increased numbers of osteoclasts per unit area of bone surface (J:98035)
• increased numbers of osteoclasts per unit area of bone surface (J:98035)
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly (J:98035)
• osteoclasts are generated more rapidly and have more prolonged life spans (J:98035)
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly (J:98035)
• osteoclasts are generated more rapidly and have more prolonged life spans (J:98035)
• decreased diameter of the femur in both sexes (J:98035)
• decreased diameter of the femur in both sexes (J:98035)
• develops by 4 months of age (J:98035)
• develops by 4 months of age (J:98035)
• lower cortical bone content at 4 months of age in the femur (J:98035)
• lower cortical bone content at 4 months of age in the femur (J:98035)
• cortical thickness of the femur reduced in males (J:98035)
• cortical thickness of the femur reduced in males (J:98035)
• increased numbers of osteoblasts seen in males (J:98035)
• increased numbers of osteoblasts seen in males (J:98035)
• trabecular bone content at epiphyses reduced (J:98035)
• trabecular bone content at epiphyses reduced (J:98035)
• 60% reduction in trabecular bone volume (J:98035)
• 60% reduction in trabecular bone volume (J:98035)

growth/size/body
• by 4 months of age (J:98035)
• by 4 months of age (J:98035)

hematopoietic system
• increased numbers of polymorphonuclear cells found in Peyer's patches (J:78189)
• increased numbers of polymorphonuclear cells found in Peyer's patches (J:78189)
• increased numbers of osteoclasts per unit area of bone surface (J:98035)
• increased numbers of osteoclasts per unit area of bone surface (J:98035)
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly (J:98035)
• osteoclasts are generated more rapidly and have more prolonged life spans (J:98035)
• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly (J:98035)
• osteoclasts are generated more rapidly and have more prolonged life spans (J:98035)

limbs/digits/tail
• decreased diameter of the femur in both sexes (J:98035)
• decreased diameter of the femur in both sexes (J:98035)

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteoporosis 166710 J:98035


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory