Phenotypes Associated with This Genotype

Genotype
MGI:3584112

• Allelic Composition: Irf8^tm1Hor/Irf8^tm1Hor; Irf4^tm1Mak/Irf4^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:84577 )

arrested B cell differentiation ( J:84577 )

• B cell development blocked in bone marrow at the pre-B cell stage

decreased dendritic cell number ( J:97716 )

• numbers of double negative dendritic cells reduced in spleen to half of control levels and very few found in thymus

decreased plasmacytoid dendritic cell number ( J:97716 )

• plasmacytoid dendritic cells in spleen reduced considerably

decreased lymphocyte cell number ( J:84577 )

absent B cells ( J:84577 )

• peripheral B cells lacking

decreased T cell number ( J:84577 )

• reduced numbers of both types of single positive T cells

abnormal pre-B cell morphology ( J:84577 )

• display cytoplasmic mu heavy chain and high levels of preBCR

• pre-B cells held up is S and G2 phase of cell cycle

increased pre-B cell number ( J:84577 )

• 5 fold increase in numbers

decreased IgM level ( J:84577 )

• soluble IgM lacking

hematopoietic system

abnormal B cell differentiation ( J:84577 )

arrested B cell differentiation ( J:84577 )

• B cell development blocked in bone marrow at the pre-B cell stage

decreased dendritic cell number ( J:97716 )

• numbers of double negative dendritic cells reduced in spleen to half of control levels and very few found in thymus

decreased plasmacytoid dendritic cell number ( J:97716 )

• plasmacytoid dendritic cells in spleen reduced considerably

decreased lymphocyte cell number ( J:84577 )

absent B cells ( J:84577 )

• peripheral B cells lacking

decreased T cell number ( J:84577 )

• reduced numbers of both types of single positive T cells

abnormal pre-B cell morphology ( J:84577 )

• display cytoplasmic mu heavy chain and high levels of preBCR

• pre-B cells held up is S and G2 phase of cell cycle

increased pre-B cell number ( J:84577 )

• 5 fold increase in numbers

decreased IgM level ( J:84577 )

• soluble IgM lacking