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Phenotypes Associated with This Genotype
Genotype
MGI:3584110
Allelic
Composition		 Irf4tm1Mak/Irf4tm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf4tm1Mak mutation (2 available); any Irf4 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased plasmacytoid dendritic cell number ( J:97716 )
• plasmacytoid dendritic cells in spleen reduced to half of control levels
increased susceptibility to bacterial infection ( J:81744 )
• Leishmania numbers increase slowly after infection
• T cell numbers drop late in the infection

hematopoietic system
decreased plasmacytoid dendritic cell number ( J:97716 )
• plasmacytoid dendritic cells in spleen reduced to half of control levels

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory