Phenotypes Associated with This Genotype

Genotype
MGI:3584109

• Allelic Composition: Irf4^tm1Mak/Irf4^tm1Mak
• Genetic Background: B6.129P2-Irf4^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive, alpha beta T cell morphology ( J:78909 )

• failed to produce Il4 or Ifn gamma after infection with Leishmania major

abnormal T-helper 1 cell differentiation ( J:78909 )

• defect in differentiation of Th1 cells

increased susceptibility to bacterial infection ( J:78909 )

• increased succeptibility to Leishmania infection

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:78909 )

• failed to produce Il4 or Ifn gamma after infection with Leishmania major

abnormal T-helper 1 cell differentiation ( J:78909 )

• defect in differentiation of Th1 cells