Phenotypes Associated with This Genotype

Genotype
MGI:3584108

• Allelic Composition: Irf4^tm1Mak/Irf4^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased B cell proliferation ( J:42683 )

decreased T cell proliferation ( J:42683 )

• reduced T cell proliferation

immune system

immune system phenotype ( J:169863 )

N • mice exhibit normal thymic and splenic gamma-delta T17 cells

abnormal spleen morphology ( J:42683 )

enlarged spleen ( J:42683 )

• spleen enlarged 3-5X by 10-15 weeks of age

absent spleen germinal center ( J:42683 )

• absent germinal centers in B cell follicles of spleen

abnormal immune system cell morphology ( J:42683 )

abnormal B cell differentiation ( J:42683 )

• decreased membrane IgMIgD B cells

• increased membrane IgM IgD B cells

arrested B cell differentiation ( J:42683 )

• late stage B cell maturation blocked

decreased dendritic cell number ( J:91043 )

• proportion of dendritic cells in spleen 50% of controls but proportion as expected in thymus

• single (+) CD4 dendritic cells reduced to about 10% of control levels in the spleen

absent plasma cells ( J:42683 )

• no plasma cells in spleen or lamina propria

increased lymphocyte cell number ( J:42683 )

• normal lymphocyte distribution at 4-5 weeks of age

• expanded numbers of T and B lymphocytes at 10-15 weeks of age

abnormal lymph node morphology ( J:42683 )

absent lymph node germinal center ( J:42683 )

• absent germinal centers in B cell follicles of lymph nodes

enlarged lymph nodes ( J:42683 )

• enlarged 10X by 10-15 weeks of age

abnormal immune system physiology ( J:42683 )

decreased B cell proliferation ( J:42683 )

decreased T cell proliferation ( J:42683 )

• reduced T cell proliferation

decreased immunoglobulin level ( J:42683 )

• all immunoglobulin classes reduced by 99% or more

increased susceptibility to Riboviria infection ( J:42683 )

• no cytotoxic T cell response to lymphocytic choriomeningitis virus

neoplasm

abnormal tumor susceptibility ( J:42683 )

• unable to reject injected tumor cells

hematopoietic system

decreased B cell proliferation ( J:42683 )

decreased T cell proliferation ( J:42683 )

• reduced T cell proliferation

abnormal B cell differentiation ( J:42683 )

• decreased membrane IgMIgD B cells

• increased membrane IgM IgD B cells

arrested B cell differentiation ( J:42683 )

• late stage B cell maturation blocked

decreased dendritic cell number ( J:91043 )

• proportion of dendritic cells in spleen 50% of controls but proportion as expected in thymus

• single (+) CD4 dendritic cells reduced to about 10% of control levels in the spleen

absent plasma cells ( J:42683 )

• no plasma cells in spleen or lamina propria

increased lymphocyte cell number ( J:42683 )

• normal lymphocyte distribution at 4-5 weeks of age

• expanded numbers of T and B lymphocytes at 10-15 weeks of age

abnormal spleen morphology ( J:42683 )

enlarged spleen ( J:42683 )

• spleen enlarged 3-5X by 10-15 weeks of age

absent spleen germinal center ( J:42683 )

• absent germinal centers in B cell follicles of spleen

decreased immunoglobulin level ( J:42683 )

• all immunoglobulin classes reduced by 99% or more

growth/size/body

enlarged spleen ( J:42683 )

• spleen enlarged 3-5X by 10-15 weeks of age