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Phenotypes Associated with This Genotype
Genotype
MGI:3584049
Allelic
Composition		 Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (27 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone epiphyseal plate morphology ( J:77683 )
• develop ectopic hypertrophy in the columnar region of tibia due to premature hypertrophic differentiation
abnormal long bone hypertrophic chondrocyte zone ( J:77683 )
• periarticular chondrocyte differentiation into columnar cells is accelerated

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory