Phenotypes Associated with This Genotype

Genotype
MGI:3584026

• Allelic Composition: Tg(Col2a1-PTHR1*H223R)BHju/Tg(Col2a1-PTHR1*H223R)BHju
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skeletal images of wild-type and Tg(Col2a1-PTHR1*H223R)BHju/Tg(Col2a1-PTHR1*H223R)BHju mice

limbs/digits/tail

abnormal hindlimb morphology ( J:77639 )

• short and deformed hindlimbs

increased diameter of tibia ( J:77639 )

short tibia ( J:77639 )

• shorter and thicker

short limbs ( J:77639 )

short hindlimb ( J:77639 )

short tail ( J:77639 )

skeleton

increased diameter of tibia ( J:77639 )

short tibia ( J:77639 )

• shorter and thicker

abnormal long bone metaphysis morphology ( J:77639 )

• metaphysis is widened in the hindlimbs

abnormal vertebrae morphology ( J:77639 )

• ossification centers of vertebrae are reduced in size

abnormal bone ossification ( J:77639 )

• chondrocyte hypertrophy and subsequent blood vessel invasion begins at the periphery of the diaphysis and not in the center of the tibia

abnormal bone mineralization ( J:77639 )

• at birth, show reduced or absent mineralization of many elements that develop by endochondral bone formation such as the supraoccipital bone, sternum, ischium and pubic bone and have severe mineralization defects of the radius and metatarsal bones

delayed endochondral bone ossification ( J:77639 )

• more pronounced than in Tg(Col2a1-PTHR1*H223R))AHju

• tibiae of newborns consist mainly of proliferative and hypertrophic chondrocytes