Phenotypes Associated with This Genotype

Genotype
MGI:3584025

• Allelic Composition: Tg(Col2a1-PTHR1*H223R)AHju/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histological sternum sections of wild-type, and mice hemizygous and homozygous for Tg(Col2a1-PTHR1*H223R)AHju

skeleton

decreased width of hypertrophic chondrocyte zone ( J:175572 )

• decrease in the number of hypertrophic chondrocytes

decreased length of long bones ( J:175572 )

abnormal vertebrae morphology ( J:77639 )

• ossification centers of vertebrae are reduced in size, however less pronounced than in homozygous transgenic mice

chondrodystrophy ( J:175572 )

• metaphyseal chondrodysplasia

abnormal bone mineralization ( J:77639 )

• at birth, show reduced or absent mineralization of many elements that develop by endochondral bone formation such as the supraoccipital bone, sternum, ischium and pubic bone, however, less pronounced than in homozygous transgenic mice

abnormal endochondral bone ossification ( J:175572 )

• impaired endochondral ossification, with extended growth plate length and absence of a clear secondary ossification center

delayed endochondral bone ossification ( J:77639 )

• sternebrae of newborns have no blood vessel invasion and the middle part of tibiae are still occupied by cartilage at E17.5, however less pronounced than in homozygous transgenic mice

abnormal chondrocyte physiology ( J:175572 )

• delay in chondrocyte differentiation

• decease in chondrocyte apoptosis