Mouse Genome Informatics
ht
    Hmga1tm1Brun/Hmga1+
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion
• plasma insulin levels but not glucose levels are significantly reduced
• glucose intolerance is 71% impaired glucose tolerance and 28% diabetes
• increased insulin sensitivity is seen in the skeletal muscle and fat
• insulin resistance is seen in the liver as seen by increased glucose production under hyperinsulinemic conditions

endocrine/exocrine glands
• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:99652