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Phenotypes Associated with This Genotype
Genotype
MGI:3583951
Allelic
Composition
Hmga1tm1Brun/Hmga1tm1Brun
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmga1tm1Brun mutation (0 available); any Hmga1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion
• plasma insulin levels but not glucose levels are significantly reduced
• glucose levels are increased 2.9 fold within 30 minutes after an intraperitoneal glucose injection compared to 2.2-fold in wild-type mice and are still elevated after 2 hours
• glucose intolerance is 40% impaired glucose tolerance and about 50% diabetes
• increased insulin sensitivity is seen in the skeletal muscle and fat
• insulin resistance is seen in the liver as seen by increased glucose production under hyperinsulinemic conditions

endocrine/exocrine glands
• islets are irregularly shaped
• islets are 50-80% smaller
• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:99652


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory