Phenotypes Associated with This Genotype

Genotype
MGI:3583951

• Allelic Composition: Hmga1^tm1Brun/Hmga1^tm1Brun
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:99652 )

• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion

decreased circulating insulin level ( J:99652 )

• plasma insulin levels but not glucose levels are significantly reduced

impaired glucose tolerance ( J:99652 )

• glucose levels are increased 2.9 fold within 30 minutes after an intraperitoneal glucose injection compared to 2.2-fold in wild-type mice and are still elevated after 2 hours

• glucose intolerance is 40% impaired glucose tolerance and about 50% diabetes

increased insulin sensitivity ( J:99652 )

• increased insulin sensitivity is seen in the skeletal muscle and fat

insulin resistance ( J:99652 )

• insulin resistance is seen in the liver as seen by increased glucose production under hyperinsulinemic conditions

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:99652 )

• islets are irregularly shaped

small pancreatic islets ( J:99652 )

• islets are 50-80% smaller

decreased insulin secretion ( J:99652 )

• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:99652