Mouse Genome Informatics
hm
    Hmga1tm1Brun/Hmga1tm1Brun
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion
• plasma insulin levels but not glucose levels are significantly reduced
• glucose levels are increased 2.9 fold within 30 minutes after an intraperitoneal glucose injection compared to 2.2-fold in wild-type mice and are still elevated after 2 hours
• glucose intolerance is 40% impaired glucose tolerance and about 50% diabetes
• increased insulin sensitivity is seen in the skeletal muscle and fat
• insulin resistance is seen in the liver as seen by increased glucose production under hyperinsulinemic conditions

endocrine/exocrine glands
• islets are irregularly shaped
• islets are 50-80% smaller
• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:99652