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Phenotypes Associated with This Genotype
Genotype
MGI:3583907
Allelic
Composition
Ins2Akita/Ins2+
Genetic
Background
C57BL/6-Ins2Akita/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2Akita mutation (13 available); any Ins2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• heterozygous males and females are hyperglycemic by 6 weeks of age (plasma glucose - 325 mg/dL); at 12 and 18 weeks of age, plasma glucose levels in males have appproximately doubled (645 mg/dL and 666 mg/dL) while levels in female mutants have increased much less (341 and 298 mg/dL respectively) (J:76224)
• heterozygous males and females are hyperglycemic by 6 weeks of age (plasma glucose - 325 mg/dL); at 12 and 18 weeks of age, plasma glucose levels in males have appproximately doubled (645 mg/dL and 666 mg/dL) while levels in female mutants have increased much less (341 and 298 mg/dL respectively) (J:76224)
• diabetic males that are hyperglycemic (plasma glucose - ~660 mg/dL) at 12 weeks show a return to euglycemia one hour after receiving 1 unit of insulin, demonstrating insulin sensitivity (J:76224)
• diabetic males that are hyperglycemic (plasma glucose - ~660 mg/dL) at 12 weeks show a return to euglycemia one hour after receiving 1 unit of insulin, demonstrating insulin sensitivity (J:76224)

immune system
• after 31-36 weeks of hyperglycemia, the number of leukocytes per retina is increased (J:99412)
• after 31-36 weeks of hyperglycemia, the number of leukocytes per retina is increased (J:99412)
• after 31-36 weeks of hyperglycemia, retinal microglia have a reactive morphology (J:99412)
• after 31-36 weeks of hyperglycemia, retinal microglia have a reactive morphology (J:99412)
• hyperglycemic male mice transplanted with pancreatic islets from wild-type B6 males become euglycemic in one week after transplant and remain euglycemic until removal of the graft (8 weeks); male mice receiving an allogeneic transplant of BALB/c wild-type islets initially become euglycemic but revert to hyperglycemia because of rejection of the graft (J:76224)
• hyperglycemic male mice transplanted with pancreatic islets from wild-type B6 males become euglycemic in one week after transplant and remain euglycemic until removal of the graft (8 weeks); male mice receiving an allogeneic transplant of BALB/c wild-type islets initially become euglycemic but revert to hyperglycemia because of rejection of the graft (J:76224)

cardiovascular system
• after 31-36 weeks of hyperglycemia, a modest increase in the number of acellular capillaries is seen in the retina (J:99412)
• after 31-36 weeks of hyperglycemia, a modest increase in the number of acellular capillaries is seen in the retina (J:99412)
• vascular permeability is increased in the retina (J:99412)
• vascular permeability is increased in the retina (J:99412)

growth/size/body
• at death heterozygous males weigh significantly less than wild-type males (J:99412)
• at death heterozygous males weigh significantly less than wild-type males (J:99412)

nervous system
• after 31-36 weeks of hyperglycemia, retinal microglia have a reactive morphology (J:99412)
• after 31-36 weeks of hyperglycemia, retinal microglia have a reactive morphology (J:99412)
• after 31-36 weeks of hyperglycemia, astrocytes close to large caliber superficial blood vessels in the retina have short projections that do not conjoin with the vessel (J:99412)
• after 31-36 weeks of hyperglycemia, astrocytes close to large caliber superficial blood vessels in the retina have short projections that do not conjoin with the vessel (J:99412)

vision/eye
• after 31-36 weeks of hyperglycemia, a modest increase in the number of acellular capillaries is seen in the retina (J:99412)
• after 31-36 weeks of hyperglycemia, a modest increase in the number of acellular capillaries is seen in the retina (J:99412)
• after 31-36 weeks of hyperglycemia, significantly more caspase-3 positive cells are seen (J:99412)
• after 31-36 weeks of hyperglycemia, significantly more caspase-3 positive cells are seen (J:99412)
• after 22 weeks of hyperglycemia, in the peripheral regions the inner nuclear layer and inner plexiform layer thickness are reduced by 15.6% and 27%, respectively, and in the central region the thickness of the inner plexiform layer is reduced by 16.7% (J:99412)
• after 22 weeks of hyperglycemia, in the peripheral regions the inner nuclear layer and inner plexiform layer thickness are reduced by 15.6% and 27%, respectively, and in the central region the thickness of the inner plexiform layer is reduced by 16.7% (J:99412)
• after 22 weeks of hyperglycemia, the number of nuclei in the retinal ganglion cell layer is reduced by 23.4% (J:99412)
• after 22 weeks of hyperglycemia, the number of nuclei in the retinal ganglion cell layer is reduced by 23.4% (J:99412)

hematopoietic system
• after 31-36 weeks of hyperglycemia, the number of leukocytes per retina is increased (J:99412)
• after 31-36 weeks of hyperglycemia, the number of leukocytes per retina is increased (J:99412)
• after 31-36 weeks of hyperglycemia, retinal microglia have a reactive morphology (J:99412)
• after 31-36 weeks of hyperglycemia, retinal microglia have a reactive morphology (J:99412)

cellular
• after 31-36 weeks of hyperglycemia, significantly more caspase-3 positive cells are seen (J:99412)
• after 31-36 weeks of hyperglycemia, significantly more caspase-3 positive cells are seen (J:99412)

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young; MODY 606391 J:99412


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory