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Phenotypes Associated with This Genotype
Genotype
MGI:3583813
Allelic
Composition
Itga7tm1Umr/Itga7tm1Umr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga7tm1Umr mutation (0 available); any Itga7 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• partial embryonic lethality between E12 and E14
• survivors are viable and fertile

muscle
• muscle fiber necrosis and mononuclear cell infiltration at the myotendinous junctions of gastrocnemius and tibialis anterior muscles (J:43840)
• reduced interdigitations in adult myotendinous junctions (J:82116)
• ends of muscle fibers abnormal, exhibiting vacuoles, dented ends, sometimes doubled in diameter (J:82116)
• skeletal muscle fibers show numerous atrophic fibers
• described in soleus and diaphragm
• skeletal muscle fibers show variation in myofiber size
• in soleus and diaphragm
• effects seen starting around 60 days of age
• fewer centrally located nuclei but huge hypertrophic fibers and extensive fibrotic areas
• no overt respiratory problems however
• variable fiber size
• centrally located nuclei
• occasional split and hypertrophic fibers
• soleus muscle of 100 day old mice shows myopathic pattern characteristic of muscular dytrophies
• muscle degeneration paralleled by endomysial connective tissue production
• foci of muscle degeneration and phagocytosis seen by around 24 days of age
• increased numbers of centrally located nuclei between 24 and 100 days of age

homeostasis/metabolism
• 6-10 fold increase in serum creatine kinase after 100 days of age

nervous system
• cells spread less when plated on laminin compared to wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory