Phenotypes Associated with This Genotype

Genotype
MGI:3583781

• Allelic Composition: Rec8^tm1Mjm/Rec8^tm1Mjm
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:99402 )

• only 12% of pups from heterozygous matings are homozygous and at E13.5 only 16% of embryos are homozygous

reproductive system

abnormal seminiferous tubule morphology ( J:99402 )

♂ • more apoptotic cells are seen in the tubules compared to wild-type mice

abnormal female reproductive system morphology ( J:99402 )

♀ • the genital tract is involuted

abnormal ovary morphology ( J:99402 )

♀ • dense fibrovascular stoma is seen

absent ovarian follicles ( J:99402 )

♀

abnormal gametogenesis ( J:99402 )

absent oocytes ( J:99402 )

♀ • complete absence of oocytes

azoospermia ( J:99402 )

♂ • no mature sperm or spermatids are seen and testes are almost depleted of primary spemtocytes by 19 days of age

abnormal female meiosis ( J:99402 )

♀ • homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes

♀ • leptotene chromosomes are seen at E16.5-E18.5 but normal pachytene nuclei are never seen

arrest of male meiosis ( J:99402 )

♂ • homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes

♂ • zygotene but not pachytene nuclei are seen

female infertility ( J:99402 )

♀

male infertility ( J:99402 )

♂

growth/size/body

postnatal growth retardation ( J:99402 )

decreased fetal size ( J:99402 )

• reduced size at E15.5

endocrine/exocrine glands

abnormal ovary morphology ( J:99402 )

♀ • dense fibrovascular stoma is seen

absent ovarian follicles ( J:99402 )

♀

abnormal seminiferous tubule morphology ( J:99402 )

♂ • more apoptotic cells are seen in the tubules compared to wild-type mice

cellular

absent oocytes ( J:99402 )

♀ • complete absence of oocytes

azoospermia ( J:99402 )

♂ • no mature sperm or spermatids are seen and testes are almost depleted of primary spemtocytes by 19 days of age

abnormal female meiosis ( J:99402 )

♀ • homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes

♀ • leptotene chromosomes are seen at E16.5-E18.5 but normal pachytene nuclei are never seen

arrest of male meiosis ( J:99402 )

♂ • homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes

♂ • zygotene but not pachytene nuclei are seen