Phenotypes Associated with This Genotype

Genotype
MGI:3583766

• Allelic Composition: Shh^Dsh/Shh^Dsh
• Genetic Background: involves: 101 * C3H * C57BL * SEC

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:16170 )

• Background Sensitivity: some are alive at E16.5-18.5 but die soon after birth, unlike on the congenic C57BL/10Rl background in which many die by E18.5

embryonic lethality during organogenesis, incomplete penetrance ( J:14105 , J:16170 )

• live until E12.5 and occasionally until E18.5 (J:14105)

limbs/digits/tail

brachydactyly ( J:16170 )

short limbs ( J:14105 , J:16170 )

• short-limbed dwarfs lacking forefeet and hindfeet (J:14105)

embryo

abnormal embryo size ( J:14105 , J:16170 )

• small head and a long trunk (J:14105)

growth/size/body

absent mouth ( J:14105 , J:16170 )

abnormal embryo size ( J:14105 , J:16170 )

• small head and a long trunk (J:14105)

microcephaly ( J:14105 , J:16170 )

hearing/vestibular/ear

abnormal ear morphology ( J:14105 , J:16170 )

• usually lack ears (J:14105)

craniofacial

absent mouth ( J:14105 , J:16170 )

reproductive system

absent external female genitalia ( J:14105 , J:16170 )

♀ • usually absent (J:14105)

♀ (J:16170)

absent external male genitalia ( J:14105 , J:16170 )

♂ • usually absent (J:14105)

♂ (J:16170)

vision/eye

cyclopia ( J:16170 )

• have a single eye that is hidden under the trunk

anophthalmia ( J:14105 )

• usually lack eyes