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Phenotypes Associated with This Genotype
Genotype
MGI:3583686
Allelic
Composition
Gcktm1Tka/Gck+
Genetic
Background
involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1Tka mutation (0 available); any Gck mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• heterozygous islets show normal insulin secretion in response to 0.1 mM or 3 mM glucose but not in response to 10 mM glucose; a less pronounced defect is noted in response to 20 mM glucose
• in contrast, heterozygous islets display a relatively normal insulin secretion in response to glibenclamide or arginine
• at 10 weeks, heterozygotes display significantly higher blood glucose levels both before and after a glucose load relative to wild-type mice
• heterozygotes exhibit mild glucose intolerance due to an impaired insulin response to glucose
• heterozygotes are viable, fertile and have normal blood glucose levels at birth
• however, ~50% of heterozygotes display mild glycosuria within a day, suggesting the development of early-onset mild diabetes mellitus

endocrine/exocrine glands
• heterozygous islets show normal insulin secretion in response to 0.1 mM or 3 mM glucose but not in response to 10 mM glucose; a less pronounced defect is noted in response to 20 mM glucose
• in contrast, heterozygous islets display a relatively normal insulin secretion in response to glibenclamide or arginine

renal/urinary system
• heterozygotes are viable, fertile and have normal blood glucose levels at birth
• however, ~50% of heterozygotes display mild glycosuria within a day, suggesting the development of early-onset mild diabetes mellitus

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:30334


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory