Mouse Genome Informatics
ht
    Gcktm1Tka/Gck+
involves: 129X1/SvJ * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• heterozygous islets show normal insulin secretion in response to 0.1 mM or 3 mM glucose but not in response to 10 mM glucose; a less pronounced defect is noted in response to 20 mM glucose
• in contrast, heterozygous islets display a relatively normal insulin secretion in response to glibenclamide or arginine
• at 10 weeks, heterozygotes display significantly higher blood glucose levels both before and after a glucose load relative to wild-type mice
• heterozygotes exhibit mild glucose intolerance due to an impaired insulin response to glucose
• however, ~50% of heterozygotes display mild glycosuria within a day, suggesting the development of early-onset mild diabetes mellitus
• heterozygotes are viable, fertile and have normal blood glucose levels at birth

endocrine/exocrine glands
• heterozygous islets show normal insulin secretion in response to 0.1 mM or 3 mM glucose but not in response to 10 mM glucose; a less pronounced defect is noted in response to 20 mM glucose
• in contrast, heterozygous islets display a relatively normal insulin secretion in response to glibenclamide or arginine

renal/urinary system
• heterozygotes are viable, fertile and have normal blood glucose levels at birth
• however, ~50% of heterozygotes display mild glycosuria within a day, suggesting the development of early-onset mild diabetes mellitus

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:30334