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Phenotypes Associated with This Genotype
Genotype
MGI:3583529
Allelic
Composition
Cys1cpk/Cys1cpk
Genetic
Background
B6(Cg)-Cys1cpk/JUnc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cys1cpk mutation (1 available); any Cys1 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die by 4 weeks of age with a few rare survivors reaching 5 weeks of age

renal/urinary system
• at around 4 weeks of age urine becomes colorless
• at 3 weeks of age the kidney occupies almost the entire abdominal cavity and constitutes about 25% of body weight
• cysts are grossly visible on cut surfaces of kidneys at 3 weeks of age with mild cystic changes already visible at E17
• progressive dilation of the proximal convoluted tubules and collecting ducts associated with intracellular vacuoles in proximal convoluted tubule cells

homeostasis/metabolism
• at around 4 weeks of age urine becomes colorless

growth/size/body
• seen at 3 weeks of age

behavior/neurological
• seen at around 4 weeks of age
• seen at around 4 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:7202


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory