Mouse Genome Informatics
hm
    Cys1cpk/Cys1cpk
B6(Cg)-Cys1cpk/JUnc
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most die by 4 weeks of age with a few rare survivors reaching 5 weeks of age

renal/urinary system
• at around 4 weeks of age urine becomes colorless
• at 3 weeks of age the kidney occupies almost the entire abdominal cavity and constitutes about 25% of body weight
• cysts are grossly visible on cut surfaces of kidneys at 3 weeks of age with mild cystic changes already visible at E17
• progressive dilation of the proximal convoluted tubules and collecting ducts associated with intracellular vacuoles in proximal convoluted tubule cells

homeostasis/metabolism
• at around 4 weeks of age urine becomes colorless

growth/size
• seen at 3 weeks of age

behavior/neurological
• seen at around 4 weeks of age
• seen at around 4 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:7202