Mouse Genome Informatics
involves: C3H * FVB/N
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: pancreatic lesions have characteristics of both parent strains; however none of the F1 and only 1 F2 had visible pancreatic cysts at the time of death

liver/biliary system
• Background Sensitivity: the liver lesion is more variable compared to mice on inbred FVB/N or C3H backgrounds

renal/urinary system
• Background Sensitivity: cyst development is intermediate compared to mice on inbred FVB/N (more severe) and C3H (less severe) backgrounds
• at 20-30 days of age, cysts are between 6.92% and 3.92% of the total kidney area

Mouse Models of Human Disease
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:73583