Phenotypes Associated with This Genotype

Genotype
MGI:3583453

• Allelic Composition: Ift88^Tg737Rpw/Ift88^Tg737Rpw
• Genetic Background: involves: C3H * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:73583 )

• Background Sensitivity: pancreatic lesions have characteristics of both parent strains; however none of the F1 and only 1 F2 had visible pancreatic cysts at the time of death

liver/biliary system

abnormal liver morphology ( J:73583 )

• Background Sensitivity: the liver lesion is more variable compared to mice on inbred FVB/N or C3H backgrounds

renal/urinary system

kidney cyst ( J:73583 )

• Background Sensitivity: cyst development is intermediate compared to mice on inbred FVB/N (more severe) and C3H (less severe) backgrounds

• at 20-30 days of age, cysts are between 6.92% and 3.92% of the total kidney area

growth/size/body

kidney cyst ( J:73583 )

• Background Sensitivity: cyst development is intermediate compared to mice on inbred FVB/N (more severe) and C3H (less severe) backgrounds

• at 20-30 days of age, cysts are between 6.92% and 3.92% of the total kidney area

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861	OMIM:263200	J:73583