Phenotypes Associated with This Genotype

Genotype
MGI:3583159

• Allelic Composition: Cd14^hdl/Cd14^hdl
• Genetic Background: C57BL/6-Cd14^hdl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal interferon secretion ( J:98908 )

• both rough and smooth LPS-induced type I interferon production was inhibited and production of interferon-alpha by macrophages infected with vesicular stomatitis virus (VSV) was decreased

decreased tumor necrosis factor secretion ( J:98908 )

• exhibited no TNF production in response to smooth lipopolysaccharide (LPS), however response to rough LPS or lipid A from Salmonella minnesota was normal

decreased susceptibility to endotoxin shock ( J:98908 )

• all homozygous mice injected with either rough or smooth LPS survived compared to controls that died within 36 hours after injection

increased susceptibility to Riboviria infection ( J:98908 )

• macrophages exposed to vesicular stomatitis virus (VSV) could not contain the infection and were more susceptible to lysis than controls