About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3583157
Allelic
Composition		 Cd14tm1Frm/Cd14+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd14tm1Frm mutation (2 available); any Cd14 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:65107 )
• macrophages exhibited a decrease in cytokine production in response to LPS
decreased interleukin-6 secretion ( J:65107 )
• decreased IL-6 production by macrophages in response to LPS
decreased tumor necrosis factor secretion ( J:65107 )
• decreased TNF production by macrophages in response to LPS

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory