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Phenotypes Associated with This Genotype
Genotype
MGI:3582996
Allelic
Composition
Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klc1tm1Gsn mutation (1 available); any Klc1 mutation (40 available)
Tg(APP695)3Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• levels of amyloid beta are consistently elevated relative to controls
• increased axonal swelling independent of amyloid deposition

homeostasis/metabolism
• levels of amyloid beta are consistently elevated relative to controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:96346


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory